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KMID : 0616120080390030213
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Korean Journal of Pharmacognosy
2008 Volume.39 No. 3 p.213 ~ p.217
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Neuroprotective Effects of Plant Extracts from Baekdu Mountain on Glutamate-induced Cytotoxicity in HT22 cells
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Li Bin
Jeong Gil-Saeng
An Ren-Bo
Lee Dong-Sung
Byun Erisa
Yoon Kwon-Ha
Kim Youn-Chul
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Abstract
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Oxidative stress is considered to play an important role in a variety of neurodegenerative disorders of central nervous system. The immortalized mouse hippocampal cell line, HT22, phenotypically resembles neuronal precursor cells but lacks functional ionotropic glutamate receptors, thus excluding excitotoxicity as a cause for glutamate triggered cell death. Therefore, HT22 cells are a useful model for studying oxidative glutamate toxicity. In this study, we examined whether the methanol extracts of some native plants at Mt. Baekdu could protect HT22-immortalized hippocampal cells against glutamate-induced oxidative stress. Seventy-eight plants sources were collected at Mt. Baekdu, and extracted with methanol. These extracts had been screened the protective effects against glutamate-induced oxidative damage in HT22 cells at the 100 and 300 . Of these, thirteen methanolic extracts, Acer mono (leaf), Artemisia stolonifera (aerial part), Carduus crispus (aerial part), Carex mongolica (whole plant), Clematis hexapetala (whole plant), Galeopsis bifida (aerial part), Galium verum (whole plant), Ganoderma lucidum (whole plant), Ixeris chinensis (whole plant), Malva verticillata (aerial part), Polygonum senticosum (whole plant), Rebes mandshricum (branch), and Taraxacum mongolicum (aerial part), showed significant protective effects against glutamate-induced oxidative damage in HT22 cells.
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KEYWORD
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Glutamate, HT22, Methanolic extracts, Mt. Baekdu, Cytoprotection
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